Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.
Identifieur interne : 000613 ( Main/Exploration ); précédent : 000612; suivant : 000614Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.
Auteurs : Urszula Radzikowska [Suisse, Pologne] ; Mei Ding [Suisse, République populaire de Chine] ; Ge Tan [Suisse] ; Damir Zhakparov [Suisse] ; Yaqi Peng [Suisse, République populaire de Chine] ; Paulina Wawrzyniak [Suisse] ; Ming Wang [Suisse, République populaire de Chine] ; Shuo Li [Suisse, Norvège] ; Hideaki Morita [Suisse, Japon] ; Can Altunbulakli [Suisse] ; Matthias Reiger [Allemagne] ; Avidan U. Neumann [Allemagne, République tchèque] ; Nonhlanhla Lunjani [Suisse] ; Claudia Traidl-Hoffmann [Suisse, Allemagne] ; Kari C. Nadeau [États-Unis] ; Liam O'Mahony [Suisse, Irlande (pays)] ; Cezmi Akdis [Suisse] ; Milena Sokolowska [Suisse]Source :
- Allergy [ 1398-9995 ] ; 2020.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Antigènes CD147 (génétique), Antigènes CD147 (immunologie), Asthme (génétique), Asthme (immunologie), Asthme (épidémiologie), Broncho-pneumopathie chronique obstructive (génétique), Broncho-pneumopathie chronique obstructive (immunologie), Broncho-pneumopathie chronique obstructive (épidémiologie), Comorbidité (MeSH), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (immunologie), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Expression des gènes (génétique), Facteurs de risque (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Humains (MeSH), Hypertension artérielle (génétique), Hypertension artérielle (immunologie), Hypertension artérielle (épidémiologie), Immunité innée (immunologie), Jeune adulte (MeSH), Maladie chronique (épidémiologie), Mâle (MeSH), Nourrisson (MeSH), Obésité (génétique), Obésité (immunologie), Obésité (épidémiologie), Sujet âgé (MeSH).
- MESH :
- génétique : Antigènes CD147, Asthme, Broncho-pneumopathie chronique obstructive, Dipeptidyl peptidase 4, Expression des gènes, Hypertension artérielle, Obésité.
- immunologie : Antigènes CD147, Asthme, Broncho-pneumopathie chronique obstructive, Dipeptidyl peptidase 4, Hypertension artérielle, Immunité innée, Obésité.
- épidémiologie : Asthme, Broncho-pneumopathie chronique obstructive, Hypertension artérielle, Maladie chronique, Obésité.
- Adolescent, Adulte, Adulte d'âge moyen, Comorbidité, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Facteurs âges, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Sujet âgé.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Angiotensin-Converting Enzyme 2 (genetics), Angiotensin-Converting Enzyme 2 (immunology), Asthma (epidemiology), Asthma (genetics), Asthma (immunology), Basigin (genetics), Basigin (immunology), COVID-19 (epidemiology), COVID-19 (genetics), COVID-19 (immunology), Child (MeSH), Child, Preschool (MeSH), Chronic Disease (epidemiology), Comorbidity (MeSH), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (immunology), Female (MeSH), Gene Expression (genetics), Humans (MeSH), Hypertension (epidemiology), Hypertension (genetics), Hypertension (immunology), Immunity, Innate (immunology), Infant (MeSH), Male (MeSH), Middle Aged (MeSH), Obesity (epidemiology), Obesity (genetics), Obesity (immunology), Pulmonary Disease, Chronic Obstructive (epidemiology), Pulmonary Disease, Chronic Obstructive (genetics), Pulmonary Disease, Chronic Obstructive (immunology), Risk Factors (MeSH), SARS-CoV-2 (genetics), SARS-CoV-2 (immunology), Young Adult (MeSH).
- MESH :
- chemical , genetics : Angiotensin-Converting Enzyme 2, Basigin, Dipeptidyl Peptidase 4.
- chemical , immunology : Angiotensin-Converting Enzyme 2, Basigin, Dipeptidyl Peptidase 4.
- epidemiology : Asthma, COVID-19, Chronic Disease, Hypertension, Obesity, Pulmonary Disease, Chronic Obstructive.
- genetics : Asthma, COVID-19, Gene Expression, Hypertension, Obesity, Pulmonary Disease, Chronic Obstructive, SARS-CoV-2.
- immunology : Asthma, COVID-19, Hypertension, Immunity, Innate, Obesity, Pulmonary Disease, Chronic Obstructive, SARS-CoV-2.
- Adolescent, Adult, Age Factors, Aged, Child, Child, Preschool, Comorbidity, Female, Humans, Infant, Male, Middle Aged, Risk Factors, Young Adult.
Abstract
BACKGROUND
Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often reported. The range of human cells and tissues targeted by SARS-CoV-2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS-CoV-2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID-19.
METHODS
We performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4
RESULTS
ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age-related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147-related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147-related genes in the lesional skin of patients with atopic dermatitis.
CONCLUSIONS
Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.
DOI: 10.1111/all.14429
PubMed: 32496587
PubMed Central: PMC7300910
Affiliations:
- Allemagne, Irlande (pays), Japon, Norvège, Pologne, République populaire de Chine, République tchèque, Suisse, États-Unis
- Bavière, Bohême centrale, Californie, Canton de Zurich, District de Haute-Bavière, District de Souabe, Guangdong, Hubei, Région de Kantō, Østlandet
- Augsbourg, Jiangmen, Munich, Oslo, Prague, Pékin, Stanford (Californie), Tokyo, Wuhan, Zurich
- Université de Zurich
Links toward previous steps (curation, corpus...)
Le document en format XML
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Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wawrzyniak, Paulina" sort="Wawrzyniak, Paulina" uniqKey="Wawrzyniak P" first="Paulina" last="Wawrzyniak">Paulina Wawrzyniak</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Chemistry and Biochemistry, University Children`s Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Clinical Chemistry and Biochemistry, University Children`s Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Children`s Research Center, University Children`s Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Children`s Research Center, University Children`s Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University and the Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University and the Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Shuo" sort="Li, Shuo" uniqKey="Li S" first="Shuo" last="Li">Shuo Li</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Morita, Hideaki" sort="Morita, Hideaki" uniqKey="Morita H" first="Hideaki" last="Morita">Hideaki Morita</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Altunbulakli, Can" sort="Altunbulakli, Can" uniqKey="Altunbulakli C" first="Can" last="Altunbulakli">Can Altunbulakli</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Reiger, Matthias" sort="Reiger, Matthias" uniqKey="Reiger M" first="Matthias" last="Reiger">Matthias Reiger</name><affiliation wicri:level="3"><nlm:affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Souabe</region><settlement type="city">Augsbourg</settlement></placeName></affiliation></author><author><name sortKey="Neumann, Avidan U" sort="Neumann, Avidan U" uniqKey="Neumann A" first="Avidan U" last="Neumann">Avidan U. Neumann</name><affiliation wicri:level="3"><nlm:affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Souabe</region><settlement type="city">Augsbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Computational Biology (ICB), Helmholtz Zentrum Munchen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Computational Biology (ICB), Helmholtz Zentrum Munchen, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Experimental Medicine (IEM), Czech Academy of Sciences, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Medicine (IEM), Czech Academy of Sciences, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Lunjani, Nonhlanhla" sort="Lunjani, Nonhlanhla" uniqKey="Lunjani N" first="Nonhlanhla" last="Lunjani">Nonhlanhla Lunjani</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Souabe</region><settlement type="city">Augsbourg</settlement></placeName></affiliation></author><author><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name><affiliation wicri:level="3"><nlm:affiliation>Sean N Parker Centre for Allergy and Asthma Research at Stanford University, Department of Medicine, Stanford University School of Medicine, Stanford, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N Parker Centre for Allergy and Asthma Research at Stanford University, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:regionArea><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="O Mahony, Liam" sort="O Mahony, Liam" uniqKey="O Mahony L" first="Liam" last="O'Mahony">Liam O'Mahony</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and School of Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medicine and School of Microbiology, APC Microbiome Ireland, National University of Ireland, Cork</wicri:regionArea><wicri:noRegion>Cork</wicri:noRegion></affiliation></author><author><name sortKey="Akdis, Cezmi" sort="Akdis, Cezmi" uniqKey="Akdis C" first="Cezmi" last="Akdis">Cezmi Akdis</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Sokolowska, Milena" sort="Sokolowska, Milena" uniqKey="Sokolowska M" first="Milena" last="Sokolowska">Milena Sokolowska</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32496587</idno><idno type="pmid">32496587</idno><idno type="doi">10.1111/all.14429</idno><idno type="pmc">PMC7300910</idno><idno type="wicri:Area/Main/Corpus">000651</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000651</idno><idno type="wicri:Area/Main/Curation">000651</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000651</idno><idno type="wicri:Area/Main/Exploration">000651</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.</title><author><name sortKey="Radzikowska, Urszula" sort="Radzikowska, Urszula" uniqKey="Radzikowska U" first="Urszula" last="Radzikowska">Urszula Radzikowska</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok</wicri:regionArea><wicri:noRegion>Bialystok</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Mei" sort="Ding, Mei" uniqKey="Ding M" first="Mei" last="Ding">Mei Ding</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Tan, Ge" sort="Tan, Ge" uniqKey="Tan G" first="Ge" last="Tan">Ge Tan</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Functional Genomic Centre Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Functional Genomic Centre Zurich, ETH Zurich/University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Zhakparov, Damir" sort="Zhakparov, Damir" uniqKey="Zhakparov D" first="Damir" last="Zhakparov">Damir Zhakparov</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Peng, Yaqi" sort="Peng, Yaqi" uniqKey="Peng Y" first="Yaqi" last="Peng">Yaqi Peng</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wawrzyniak, Paulina" sort="Wawrzyniak, Paulina" uniqKey="Wawrzyniak P" first="Paulina" last="Wawrzyniak">Paulina Wawrzyniak</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Chemistry and Biochemistry, University Children`s Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Clinical Chemistry and Biochemistry, University Children`s Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Children`s Research Center, University Children`s Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Children`s Research Center, University Children`s Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University and the Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University and the Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Shuo" sort="Li, Shuo" uniqKey="Li S" first="Shuo" last="Li">Shuo Li</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Morita, Hideaki" sort="Morita, Hideaki" uniqKey="Morita H" first="Hideaki" last="Morita">Hideaki Morita</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Altunbulakli, Can" sort="Altunbulakli, Can" uniqKey="Altunbulakli C" first="Can" last="Altunbulakli">Can Altunbulakli</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Reiger, Matthias" sort="Reiger, Matthias" uniqKey="Reiger M" first="Matthias" last="Reiger">Matthias Reiger</name><affiliation wicri:level="3"><nlm:affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Souabe</region><settlement type="city">Augsbourg</settlement></placeName></affiliation></author><author><name sortKey="Neumann, Avidan U" sort="Neumann, Avidan U" uniqKey="Neumann A" first="Avidan U" last="Neumann">Avidan U. Neumann</name><affiliation wicri:level="3"><nlm:affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Souabe</region><settlement type="city">Augsbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Computational Biology (ICB), Helmholtz Zentrum Munchen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Computational Biology (ICB), Helmholtz Zentrum Munchen, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institute of Experimental Medicine (IEM), Czech Academy of Sciences, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Medicine (IEM), Czech Academy of Sciences, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Lunjani, Nonhlanhla" sort="Lunjani, Nonhlanhla" uniqKey="Lunjani N" first="Nonhlanhla" last="Lunjani">Nonhlanhla Lunjani</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Souabe</region><settlement type="city">Augsbourg</settlement></placeName></affiliation></author><author><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name><affiliation wicri:level="3"><nlm:affiliation>Sean N Parker Centre for Allergy and Asthma Research at Stanford University, Department of Medicine, Stanford University School of Medicine, Stanford, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sean N Parker Centre for Allergy and Asthma Research at Stanford University, Department of Medicine, Stanford University School of Medicine, Stanford</wicri:regionArea><placeName><settlement type="city">Stanford (Californie)</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="O Mahony, Liam" sort="O Mahony, Liam" uniqKey="O Mahony L" first="Liam" last="O'Mahony">Liam O'Mahony</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine and School of Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medicine and School of Microbiology, APC Microbiome Ireland, National University of Ireland, Cork</wicri:regionArea><wicri:noRegion>Cork</wicri:noRegion></affiliation></author><author><name sortKey="Akdis, Cezmi" sort="Akdis, Cezmi" uniqKey="Akdis C" first="Cezmi" last="Akdis">Cezmi Akdis</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author><author><name sortKey="Sokolowska, Milena" sort="Sokolowska, Milena" uniqKey="Sokolowska M" first="Milena" last="Sokolowska">Milena Sokolowska</name><affiliation wicri:level="4"><nlm:affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Christine Kühne - Center for Research and Education (CK-CARE), Davos</wicri:regionArea><wicri:noRegion>Davos</wicri:noRegion></affiliation></author></analytic><series><title level="j">Allergy</title><idno type="eISSN">1398-9995</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Angiotensin-Converting Enzyme 2 (genetics)</term><term>Angiotensin-Converting Enzyme 2 (immunology)</term><term>Asthma (epidemiology)</term><term>Asthma (genetics)</term><term>Asthma (immunology)</term><term>Basigin (genetics)</term><term>Basigin (immunology)</term><term>COVID-19 (epidemiology)</term><term>COVID-19 (genetics)</term><term>COVID-19 (immunology)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Chronic Disease (epidemiology)</term><term>Comorbidity (MeSH)</term><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Dipeptidyl Peptidase 4 (immunology)</term><term>Female (MeSH)</term><term>Gene Expression (genetics)</term><term>Humans (MeSH)</term><term>Hypertension (epidemiology)</term><term>Hypertension (genetics)</term><term>Hypertension (immunology)</term><term>Immunity, Innate (immunology)</term><term>Infant (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Obesity (epidemiology)</term><term>Obesity (genetics)</term><term>Obesity (immunology)</term><term>Pulmonary Disease, Chronic Obstructive (epidemiology)</term><term>Pulmonary Disease, Chronic Obstructive (genetics)</term><term>Pulmonary Disease, Chronic Obstructive (immunology)</term><term>Risk Factors (MeSH)</term><term>SARS-CoV-2 (genetics)</term><term>SARS-CoV-2 (immunology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antigènes CD147 (génétique)</term><term>Antigènes CD147 (immunologie)</term><term>Asthme (génétique)</term><term>Asthme (immunologie)</term><term>Asthme (épidémiologie)</term><term>Broncho-pneumopathie chronique obstructive (génétique)</term><term>Broncho-pneumopathie chronique obstructive (immunologie)</term><term>Broncho-pneumopathie chronique obstructive (épidémiologie)</term><term>Comorbidité (MeSH)</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Dipeptidyl peptidase 4 (immunologie)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Expression des gènes (génétique)</term><term>Facteurs de risque (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Hypertension artérielle (génétique)</term><term>Hypertension artérielle (immunologie)</term><term>Hypertension artérielle (épidémiologie)</term><term>Immunité innée (immunologie)</term><term>Jeune adulte (MeSH)</term><term>Maladie chronique (épidémiologie)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Obésité (génétique)</term><term>Obésité (immunologie)</term><term>Obésité (épidémiologie)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Angiotensin-Converting Enzyme 2</term><term>Basigin</term><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Angiotensin-Converting Enzyme 2</term><term>Basigin</term><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Asthma</term><term>COVID-19</term><term>Chronic Disease</term><term>Hypertension</term><term>Obesity</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asthma</term><term>COVID-19</term><term>Gene Expression</term><term>Hypertension</term><term>Obesity</term><term>Pulmonary Disease, Chronic Obstructive</term><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes CD147</term><term>Asthme</term><term>Broncho-pneumopathie chronique obstructive</term><term>Dipeptidyl peptidase 4</term><term>Expression des gènes</term><term>Hypertension artérielle</term><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD147</term><term>Asthme</term><term>Broncho-pneumopathie chronique obstructive</term><term>Dipeptidyl peptidase 4</term><term>Hypertension artérielle</term><term>Immunité innée</term><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Asthma</term><term>COVID-19</term><term>Hypertension</term><term>Immunity, Innate</term><term>Obesity</term><term>Pulmonary Disease, Chronic Obstructive</term><term>SARS-CoV-2</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Asthme</term><term>Broncho-pneumopathie chronique obstructive</term><term>Hypertension artérielle</term><term>Maladie chronique</term><term>Obésité</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Child</term><term>Child, Preschool</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often reported. The range of human cells and tissues targeted by SARS-CoV-2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS-CoV-2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID-19.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age-related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147-related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147-related genes in the lesional skin of patients with atopic dermatitis.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32496587</PMID><DateCompleted><Year>2020</Year><Month>12</Month><Day>07</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1398-9995</ISSN><JournalIssue CitedMedium="Internet"><Volume>75</Volume><Issue>11</Issue><PubDate><Year>2020</Year><Month>11</Month></PubDate></JournalIssue><Title>Allergy</Title><ISOAbbreviation>Allergy</ISOAbbreviation></Journal><ArticleTitle>Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors.</ArticleTitle><Pagination><MedlinePgn>2829-2845</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/all.14429</ELocationID><Abstract><AbstractText Label="BACKGROUND">Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide, and novel clinical presentations of COVID-19 are often reported. The range of human cells and tissues targeted by SARS-CoV-2, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS-CoV-2 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID-19.</AbstractText><AbstractText Label="METHODS">We performed RNA sequencing and explored available RNA-Seq databases to study gene expression and co-expression of ACE2, CD147 (BSG), and CD26 (DPP4) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4<sup>+</sup> and CD8<sup>+</sup> T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID-19 risk factor status.</AbstractText><AbstractText Label="RESULTS">ACE2 and TMPRSS2 were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (BSG), cyclophilins (PPIA andPPIB), CD26 (DPP4), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age-related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2- and CD147-related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147-related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147-related genes in the lesional skin of patients with atopic dermatitis.</AbstractText><AbstractText Label="CONCLUSIONS">Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.</AbstractText><CopyrightInformation>© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Radzikowska</LastName><ForeName>Urszula</ForeName><Initials>U</Initials><Identifier Source="ORCID">0000-0002-7341-9764</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ding</LastName><ForeName>Mei</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Ge</ForeName><Initials>G</Initials><Identifier Source="ORCID">0000-0003-0026-8739</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Functional Genomic Centre Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhakparov</LastName><ForeName>Damir</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Yaqi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wawrzyniak</LastName><ForeName>Paulina</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0001-9641-2103</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Clinical Chemistry and Biochemistry, University Children`s Hospital Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Children`s Research Center, University Children`s Hospital Zurich, Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Ming</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0002-8560-3964</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University and the Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Shuo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morita</LastName><ForeName>Hideaki</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0003-0928-8322</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Altunbulakli</LastName><ForeName>Can</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0003-2264-7377</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reiger</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neumann</LastName><ForeName>Avidan U</ForeName><Initials>AU</Initials><AffiliationInfo><Affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Computational Biology (ICB), Helmholtz Zentrum Munchen, Munich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Experimental Medicine (IEM), Czech Academy of Sciences, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lunjani</LastName><ForeName>Nonhlanhla</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Traidl-Hoffmann</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0001-5085-5179</Identifier><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum Munchen, Augsburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nadeau</LastName><ForeName>Kari C</ForeName><Initials>KC</Initials><Identifier Source="ORCID">0000-0002-2146-2955</Identifier><AffiliationInfo><Affiliation>Sean N Parker Centre for Allergy and Asthma Research at Stanford University, Department of Medicine, Stanford University School of Medicine, Stanford, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Mahony</LastName><ForeName>Liam</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0003-4705-3583</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine and School of Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akdis</LastName><ForeName>Cezmi</ForeName><Initials>C</Initials><Identifier Source="ORCID">0000-0001-8020-019X</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sokolowska</LastName><ForeName>Milena</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-9710-6685</Identifier><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne - Center for Research and Education (CK-CARE), Davos, Switzerland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Allergy</MedlineTA><NlmUniqueID>7804028</NlmUniqueID><ISSNLinking>0105-4538</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C497886">BSG protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>136894-56-9</RegistryNumber><NameOfSubstance 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MMWR Morb Mortal Wkly Rep. 2020;69(14):422-426.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Irlande (pays)</li><li>Japon</li><li>Norvège</li><li>Pologne</li><li>République populaire de Chine</li><li>République tchèque</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bavière</li><li>Bohême centrale</li><li>Californie</li><li>Canton de Zurich</li><li>District de Haute-Bavière</li><li>District de Souabe</li><li>Guangdong</li><li>Hubei</li><li>Région de Kantō</li><li>Østlandet</li></region><settlement><li>Augsbourg</li><li>Jiangmen</li><li>Munich</li><li>Oslo</li><li>Prague</li><li>Pékin</li><li>Stanford (Californie)</li><li>Tokyo</li><li>Wuhan</li><li>Zurich</li></settlement><orgName><li>Université de Zurich</li></orgName></list><tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Radzikowska, Urszula" sort="Radzikowska, Urszula" uniqKey="Radzikowska U" first="Urszula" 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sortKey="Lunjani, Nonhlanhla" sort="Lunjani, Nonhlanhla" uniqKey="Lunjani N" first="Nonhlanhla" last="Lunjani">Nonhlanhla Lunjani</name><name sortKey="Morita, Hideaki" sort="Morita, Hideaki" uniqKey="Morita H" first="Hideaki" last="Morita">Hideaki Morita</name><name sortKey="O Mahony, Liam" sort="O Mahony, Liam" uniqKey="O Mahony L" first="Liam" last="O'Mahony">Liam O'Mahony</name><name sortKey="Peng, Yaqi" sort="Peng, Yaqi" uniqKey="Peng Y" first="Yaqi" last="Peng">Yaqi Peng</name><name sortKey="Peng, Yaqi" sort="Peng, Yaqi" uniqKey="Peng Y" first="Yaqi" last="Peng">Yaqi Peng</name><name sortKey="Radzikowska, Urszula" sort="Radzikowska, Urszula" uniqKey="Radzikowska U" first="Urszula" last="Radzikowska">Urszula Radzikowska</name><name sortKey="Sokolowska, Milena" sort="Sokolowska, Milena" uniqKey="Sokolowska M" first="Milena" last="Sokolowska">Milena Sokolowska</name><name sortKey="Sokolowska, Milena" sort="Sokolowska, Milena" uniqKey="Sokolowska M" first="Milena" last="Sokolowska">Milena Sokolowska</name><name sortKey="Tan, Ge" sort="Tan, Ge" uniqKey="Tan G" first="Ge" last="Tan">Ge Tan</name><name sortKey="Tan, Ge" sort="Tan, Ge" uniqKey="Tan G" first="Ge" last="Tan">Ge Tan</name><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name><name sortKey="Wawrzyniak, Paulina" sort="Wawrzyniak, Paulina" uniqKey="Wawrzyniak P" first="Paulina" last="Wawrzyniak">Paulina Wawrzyniak</name><name sortKey="Wawrzyniak, Paulina" sort="Wawrzyniak, Paulina" uniqKey="Wawrzyniak P" first="Paulina" last="Wawrzyniak">Paulina Wawrzyniak</name><name sortKey="Wawrzyniak, Paulina" sort="Wawrzyniak, Paulina" uniqKey="Wawrzyniak P" first="Paulina" last="Wawrzyniak">Paulina Wawrzyniak</name><name sortKey="Wawrzyniak, Paulina" sort="Wawrzyniak, Paulina" uniqKey="Wawrzyniak P" first="Paulina" last="Wawrzyniak">Paulina Wawrzyniak</name><name sortKey="Zhakparov, Damir" sort="Zhakparov, Damir" uniqKey="Zhakparov D" first="Damir" last="Zhakparov">Damir Zhakparov</name></country><country name="Pologne"><noRegion><name sortKey="Radzikowska, Urszula" sort="Radzikowska, Urszula" uniqKey="Radzikowska U" first="Urszula" last="Radzikowska">Urszula Radzikowska</name></noRegion></country><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Ding, Mei" sort="Ding, Mei" uniqKey="Ding M" first="Mei" last="Ding">Mei Ding</name></region><name sortKey="Peng, Yaqi" sort="Peng, Yaqi" uniqKey="Peng Y" first="Yaqi" last="Peng">Yaqi Peng</name><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Li, Shuo" sort="Li, Shuo" uniqKey="Li S" first="Shuo" last="Li">Shuo Li</name></region></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Morita, Hideaki" sort="Morita, Hideaki" uniqKey="Morita H" first="Hideaki" last="Morita">Hideaki Morita</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Reiger, Matthias" sort="Reiger, Matthias" uniqKey="Reiger M" first="Matthias" last="Reiger">Matthias Reiger</name></region><name sortKey="Neumann, Avidan U" sort="Neumann, Avidan U" uniqKey="Neumann A" first="Avidan U" last="Neumann">Avidan U. Neumann</name><name sortKey="Neumann, Avidan U" sort="Neumann, Avidan U" uniqKey="Neumann A" first="Avidan U" last="Neumann">Avidan U. Neumann</name><name sortKey="Traidl Hoffmann, Claudia" sort="Traidl Hoffmann, Claudia" uniqKey="Traidl Hoffmann C" first="Claudia" last="Traidl-Hoffmann">Claudia Traidl-Hoffmann</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Neumann, Avidan U" sort="Neumann, Avidan U" uniqKey="Neumann A" first="Avidan U" last="Neumann">Avidan U. Neumann</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name></region></country><country name="Irlande (pays)"><noRegion><name sortKey="O Mahony, Liam" sort="O Mahony, Liam" uniqKey="O Mahony L" first="Liam" last="O'Mahony">Liam O'Mahony</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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